Branded actives

Metabolic health

Bioavailableberberine extract.

Berberine absorption made effective at a lower dose, for a healthier metabolism.

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NLT 40%Berberine hydrochloride
8×Higher absorption
300 mgRecommended daily dose

A man in his fifties laughing with a friend on a morning walk

Why Berbisol

Standard berberine
barely gets absorbed.

Berberine, formulated for better delivery.

Berberine is a naturally occurring bioactive compound, extensively studied for its interaction with AMPK, a key cellular pathway in energy metabolism and metabolic health. Yet its potential is closely linked to how well the body can absorb and use it: conventional berberine has inherently low bioavailability, due to poor water solubility, extensive first-pass metabolism and rapid systemic clearance.

Berbisol™ is designed to address these delivery challenges at their source. Its advanced formulation improves berberine’s dispersibility, absorption and overall bioavailability, helping unlock the true potential of berberine for healthy metabolism.

<1%
Absorbed from a standard extract
Requiring a high daily dose of 1 to 1.5 g.
02
Poor absorption
Berberine’s poor solubility and absorption in the gut mean less of it reaches systemic circulation.
03
First-pass metabolism
Extensive degradation in the liver before it reaches the bloodstream.
04
Rapid elimination
What little berberine is absorbed into the blood is quickly eliminated.

The approach

Improving bioavailability,
reducing the dose.

Made to survive gastrointestinal conditions. BioRelay™ true water solution, powered by LIMAN™, microencapsulates the berberine in lecithin. Berbisol™ also contains natural bioenhancers for better efficacy. A second variant, Berbisol™ Plus, adds a spore-forming probiotic strain (Bacillus subtilis) that produces nitroreductase, the enzyme critical for converting berberine to dihydroberberine, its absorbable form.

Berbisol™Conventional berberine

0 h4 h8 h12 h24 h36 h48 h

Higher Free berberine concentration in plasma, single 300 mg dose; 8× the exposure (AUC) and 3× the peak (Cmax)

01
Lecithin-based microencapsulation
Improves aqueous dispersion, imparts stability in the acidic environment and reduces breakdown in the liver, improving absorption.
02
Berbisol™ and Berbisol™ Plus
Two variants, each uniquely formulated to meet metabolic needs.
03
Natural bioenhancers
A small blend of natural food additives, for better efficacy.

Bioavailable berberine extract

Berberine HCl+Natural bioenhancers

Plus

Enriched with probiotics

Berbisol™+Spore-forming probiotic

The evidence

Comparative human
pharmacokinetics.

One human pharmacokinetic study, under publication: how much more berberine Berbisol™ gets into the blood.

8× more berberine absorbed.

Higher AUC, at an equal dose

Three times higher concentration.

In the blood

One small dose.

300 mg per day

Pharmacokinetic study · Under publication

Comparative human pharmacokinetics.

30 adults · 300 mg, single dose · crossover · vs conventional berberineUnder publication

Berbisol™Against conventional berberine hydrochloride extract

3×Higher Cmax: higher concentration in the blood

8×Higher AUC per mg: higher bioavailability

Berbisol™ PlusAgainst conventional berberine hydrochloride extract

2.7×Higher Cmax: higher concentration in the blood

7.8×Higher AUC per mg: higher bioavailability

Comparative pharmacokinetic profileFree berberine in the blood after a single 300 mg dose of each

Swipe the chart to see all 48 hours

Conventional berberine HClBerbisol™Berbisol™ Plus

Read the full study

The same man at home in the kitchen, slicing vegetables by the window — What the study found

Higher absorption of berberine
*from Berbisol^™, at an equal dose.*

Proving its higher bioavailability.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Know your ingredient

Berbisol^™

For centuries, Indian barberry (Berberis aristata), known in Ayurveda as daruharidra, has been valued as an important botanical in traditional wellness practices, across more than 2,500 years of Ayurveda and Traditional Chinese Medicine. Its roots are naturally rich in berberine, an isoquinoline alkaloid that has been the subject of extensive modern scientific research, and its preparations have traditionally been used for digestion and skin health. Conventional berberine has inherently low bioavailability; Berbisol™ overcomes this challenge with an advanced formulation designed to enhance it.

NLT 40%Berberine HCl
Standardized, from a root-only extraction.
LecithinMicroencapsulation
Improves dispersibility and stability, and reduces degradation.
BioenhancersNatural
A small blend of natural food additives, for better bioavailability.
ProbioticBerbisol™ Plus
The Plus grade’s probiotic strain, a differentiation that improves absorption.

Healthy metabolism made convenient, from a smaller once-a-day dose.

Formulation

How it’s made.

Berbisol™ is made with lecithin-based microencapsulation and standardized to NLT 40% berberine hydrochloride. 300 mg a day, in capsules and coated tablets.

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NLT 40% berberine HCl
Standardized, from a root-only extraction.
Lecithin microencapsulation
Improves dispersibility and stability, and reduces degradation.
Natural bioenhancers
A small blend of natural food additives, for better efficacy.
Berbisol™ Plus
Adds a spore-forming probiotic strain, for absorption.

How the formula builds

Botanical: Berberis aristata, root
Key active: Berberine hydrochloride
Standardization: NLT 40% berberine hydrochloride
Technology: BioRelay™ true water solution, powered by LIMAN™
Grades: Berbisol™: with natural bioenhancers · Berbisol™ Plus: with a spore-forming GRAS Bacillus subtilis strain
Dose: 300 mg/day
Certification: Halal · Kosher
Positioning: Metabolic health · blood glucose management · weight management · gut health