Branded actives Maxicuma®

Ultra low dosecurcumin.

Clinically studied for better joint health.

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  • 30 daysOnset of action
  • 79%Reduction in pain score
  • NLT 40%Total curcuminoids
A man in his fifties planting in his garden among marigolds

Why Maxicuma

Most curcumin never
reaches the blood.

Curcumin is the most researched constituent of turmeric, trusted in Ayurveda for 4,000 years for the joints, the muscles and immunity. But raw turmeric holds only 2 to 3% curcumin, and less than 1% of a dose reaches the blood as free curcumin, the form that actually works. Maxicuma® is formulated to address this bioavailability challenge with BioRelay™ true water solution, so more free curcumin reaches systemic circulation.

  1. 01

    Poor absorption

    Curcumin has poor aqueous solubility, which limits its absorption.

  2. 02

    Unstable in the gut

    Curcumin has limited stability in gastrointestinal conditions, and is rapidly metabolised.

  3. 03

    Broken down fast

    What is absorbed is quickly converted into inactive forms.

  4. 04

    Numbers that mislead

    Not all “curcumin” measurements represent free curcumin.

The approach

Made to survive
the gastrointestinal tract.

BioRelay™ true water solution, powered by LIMAN™, microencapsulates the curcuminoids in lecithin, for better dispersion, stability in the acidic environment of the gut, and better absorption as more free curcumin.

Maxicuma®Standard curcumin
Standard curcumin: >50% excreted unabsorbed, ~15% degraded, <1% reaches the blood as free curcumin
  1. 01
    Dispersibility

    Lecithin-based microencapsulation improves aqueous dispersion.

  2. 02
    Stability

    Stable in the acidic gut environment, with less breakdown.

  3. 03
    Absorption

    Improved bioavailability: more free curcumin in systemic circulation, effective at a low dose.

Instant cold-water dispersibleNeutral taste
Evolution of curcumin dosageMaxicuma® delivers superior efficacy at an ultra low dose, cost-effectively
  1. Standard extract2,000 mg
  2. 1st generation, adjuvants1,500 mg
  3. 2nd generation, phospholipids1,000 mg
  4. 3rd generation, synthetic bioenhancers250–500 mg
  5. Maxicuma®100–250 mg

The evidence

Higher uptake.
Efficacy at an ultra low dose.

Two human studies, both published: how well Maxicuma® is absorbed, and what it does for the joints.

Pharmacokinetic study · Published

Higher uptake of curcuminoids.

14 adults · crossover · equal dose · vs micronized curcumin 95%Current Research in Complementary & Alternative Medicine, 2023

1.6×Higher Tmax
2.4×Higher Cmax
3×Higher AUC
172×More free curcumin
Read the full study

Clinical study · Published

Efficacy at an ultra low dose.

180 adults · 100 or 250 mg/day · 90 days · vs placeboEuropean Journal of Integrative Medicine, 2025

By day 90Change from baseline; p < 0.0001 vs placebo100 mg250 mg
Reduction in pain score (VAS)
70%
79%
Lower WOMAC total score
70%
79%
Reduction in WOMAC stiffness score
72%
80%
Improved mobility (physical performance)
93%
131%
Pain over 90 daysVisual analogue scale, lower is better
Pain on the visual analogue scale over 90 days: placebo, Maxicuma 100 mg and 250 mg010203040506070BaselineDay 30Day 45Day 60Day 90Pain, VAS score********
PlaceboMaxicuma® 100 mgMaxicuma® 250 mg

Significant from day 30 at both doses. *p < 0.0001 vs placebo.

Read the full study
The same man lifting a crate of firewood in his garage

What the study found

More joint comfort,
better physical function
from day 30.

Further benefit by day 90 with regular Maxicuma®, at 100 and 250 mg a day.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Turmeric rhizome

Know your ingredient

Maxicuma®

Curcuma longa, trusted in Ayurveda for 4,000 years and known for liver, muscle, joint, immune and skin support. Of its hundred-odd molecular constituents, curcumin is the most researched, and it makes up only 2 to 3% of the rhizome. High doses are needed for efficacy, yet 90% is excreted. Maxicuma®, our ultra low dose curcumin formulated with BioRelay™ technology and backed by science, resolves the high-dose, low-absorption problem: a consumer-friendly curcumin for healthy joints.

  1. >40%Total curcuminoids

    Extracted from the Curcuma longa rhizome and formulated with lecithin-based microencapsulation.

  2. UniformDispersion

    Better aqueous dispersibility.

  3. LowDose

    Compact, synergistic formulations.

  4. VersatileApplication

    Low dose combined with dispersion opens more formulation options.

Curcumin built for formulation convenience and a great consumer experience.

Formulation

How it’s made.

Curcuma longa extract, microencapsulated in a lecithin-based coating and standardized to NLT 40% curcuminoids, with instant cold-water dispersibility and a neutral taste. 100 or 250 mg a day.

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Lecithin-based microencapsulation
Botanical
Curcuma longa, turmeric rhizome
Key actives
Curcuminoids
Standardization
NLT 40% curcuminoids
Technology
BioRelay™ true water solution, powered by LIMAN™ (lecithin-based microencapsulation)
Dose
100 mg or 250 mg, one a day
Attribute
Instant cold-water dispersible, neutral taste
Status
Patented · Self-affirmed GRAS
Certification
Halal · Kosher
Positioning
Joint health · sports and active nutrition

Certification

Application formats

CapsulesTabletsGummiesShots and beveragesRTM powdersLozengesMouth meltsBars
The same man resting on the sofa, drinking a golden turmeric drink

Also from Ennature

Next step

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